MD7002: Analysis and Interpretation of Clinical Data Essay Assignment Help
Question
MD7002: This is a Biomedical science assignment for the University of Chester which assesses the student’s ability to comprehend and evaluate the typical methods that are applied in daily practice for critical analysis of Biomedical Science related data. Additionally, the academic writing abilities of the students are also assessed in this assignment. For this assessment, the student is required to choose one lab test related to the course, which needs to be evaluated in terms of its clinical technique of the test.
Solution
In providing MSc Biomedical Science Assignments Help here, our experts have written a comprehensive solution in which anti-dsDNA testing has been evaluated using the Farr-RIA method to diagnose systemic lupus erythematosus. The solution is divided into a brief Introduction, Principles of Farr-RIA, Comparative analysis of Farr-RIA with other anti-dsDNA antibody Tests, Practice and research implications, followed by a brief Conclusion. We have provided half of the solution here for your reference:
Introduction
This introductory paragraph written by OAS experts while providing MD7002 Evaluative Essay Assignment Help presents a foregrounding to this diagnostic procedure which is to be evaluated through this essay. You can read a snippet of the complete introduction here:
Based on the evaluation of serum anti-dsDNA antibodies, the Farr radioimmunoassay (Farr-RIA) is a widely used diagnostic test for Systemic lupus erythematosus (SLE) used and is often considered as gold standard diagnostic.
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Principle of Farr-RIA
In the next section, the basic principles of the diagnostic test have been discussed in detail. This section entails the advantages and limitations that accompany Farr-RIA testing.
The routine use of Farr-RIA is attributed to its high specificity in the diagnosis of SLE through the accurate detection of high avidity anti-dsDNA antibodies. The “radio” component of this test arises from the use of radioactive iodine-labelled dsDNA molecules to bind to the antidsDNA antibodies in the patient’s serum (Lakota et al., 2019). These immune complexes are then specifically precipitated using ammonium sulphate and this precipitate is then qualitatively and quantitatively analysed. Various advantages of the Farr-RIA method can be attributed to specific aspects of its procedure. For instance, this test’s ability to detect high avidity anti-dsDNA antibodies can be attributed to the use of native, non-fixed dsDNA that closely resembles the genetic material of live host cells (Duus et al., 2017; Wang & Xia., 2019). As such, this test takes advantage of the high binding potential of anti-dsDNA antibodies and the radiolabelled dsDNA molecules.
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Comparative analysis of Farr-RIA with other anti-dsDNA antibody tests
Following this, evidence from scholarly literature as well as module learnings have been utilized to provide a comparative evaluation of Farr-RIA with any other anti-dsDNA antibody tests that are available.
In addition to the Farr-RIA, other anti-dsDNA antibody tests are also of value in SLE diagnosis. The Crithidia luciliae indirect immunofluorescence test (CLIFT) is one such test, wherein anti-dsDNA antibodies are detected upon conjugation with the mitrochondrialkinetoplast of Crithidia luciliae (Lakota et al., 2019). Unlike Farr-RIA, CLIFT is both highly sensitive and specific because the kinetoplast comprises only dsDNA molecules with no other nuclear material, which reduces the risk of false positive reports (Wang & Xia., 2019). However, CLIFT is primarily a qualitative test and only semiquantitative in nature, making it only effective for diagnosis and not for assessing disease severity (Cockx et al., 2022; Lakota et al., 2019). As such, CLIFT testing is often followed by quantitative Farr-RIA to detect disease severity, which informs patient management (Orme et al., 2022). Moreover, CLIFT is a laborious test that demands more skilled technicians, which limits its use in routine diagnostics (Orme et al., 2022).
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Practice and research implications
Next, the practicality of the diagnostic test chosen has been analyzed in detail to explore the challenges that might accompany this laboratory test. We have provided half of this section below:
A key concern regarding the utility of Farr-RIA is radioactivity, which limits its utility in low-infrastructural healthcare settings (Ghiggeri et al., 2019). As such, a key research implication is to develop similarly specific and more sensitive quantitative tests that can ensure a comprehensive diagnosis of SLE.
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Conclusion
Here, our experts have provided a brief conclusion elaborating upon whether this test is feasible or not.
Despite the established gold standard status, Farr-RIA has both advantages and disadvantages in diagnosis of SLE when compared to other diagnostic tests like ELISA and CLIFT.
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