HCS329: Referral / Deferral Clinical Case Study Assignment Help
Question
HCS329: This assignment for the University of Sunderland assesses the student’s ability to analyze and interpret clinical and laboratory data related to a particular case study. A clinical case study has been provided to the students for which the student is supposed to elaborate on how each of the disorders’ diagnoses was influenced by the lab data presented. In addition, the assessment also demands the student to compare the pathogenes of the stated state, contrast the laboratory tests employed in this domain, and subsequently utilize laboratory data to evaluate potential illness severity and clinical consequences.
Solution
This assessment constitutes a part of the BSc Biomedical Sciences course for which many students need assignment help. This is because the assignment demands an in-depth knowledge of Hematology and Transfusion Sciences. OAS experts possess extensive academic backgrounds, and subject-matter expertise, based on which they have developed a comprehensively written HCS329 Case Study Analysis and Solution.
Question 1
In writing the answer to this first question, each patient’s blood type and any antibodies in the plasma have been determined through an extensive analysis of the laboratory data. Our experts provide top-quality University of Sunderland Assignment Help by supporting this analysis with evidence-based findings.
Patient 1
Based on the laboratory data provided in Table 1, it can be observed that Patient 1’s plasma contains Anti-D antibodies. According to week 1 module, this is indicated by the presence of agglutination (+++) in the control column when Anti-D reagent is added, along with the absence of agglutination in the A and B cells. The absence of agglutination in the Aand B cells indicates the absence of Anti-A and Anti-B antibodies, respectively (NHS, 2021).
Patient 2
From the data provided in Table 1, it can be inferred that Patient 2 has plasma containing Anti-D antibodies. This is evident from the strong agglutination observed in the control column (+++), along with the absence of agglutination in the A and B cells. The absence of agglutination in the A and B cells indicates the absence of Anti-A and Anti-B antibodies, respectively. In Table 2, the Antibody Identification Panel results reveal that Patient 2’s plasma reacts strongly (+++) with the cells in wells 2, 6, and 10, while no reaction is observed in the remaining wells.
If you want to get Biomedical Sciences Assignment help in England from the best industry experts, Call us at +61 871501720 today.
Question 2
The following question demands the student to analyze the clinical and laboratory data critically in order to identify any potential clinical condition that might be affecting both the patients’ pregnancies. We have provided half of the solution for your guidance here.
Patient 1
The clinical and laboratory data for patient 1 indicate the presence of Anti-D antibodies in her plasma. According to week 4 mini lecture, this finding, along with the fact that she is Rh(D) negative, suggests a potential clinical condition known as Rh(D) alloimmunization. Rh(D) alloimmunization occurs when an Rh(D) negative individual, such as Patient 1, is sensitized to the Rh(D) antigen through exposure to Rh(D) positive blood, typically during pregnancy or blood transfusion (Ahn et al., 2022).
Patient 2
The clinical and laboratory data reveal the presence of Anti-D antibodies in her plasma, indicating a potential diagnosis of Rh(D) alloimmunization as well. The presence of Anti-D antibodies in patient 2’s plasma, along with her Rh(D) positive blood type, suggests that she has been sensitized to the Rh(D) antigen, most likely during her previous pregnancy or a blood transfusion. Patient 2’s history of requiring a blood transfusion due to post-partum haemorrhage during her latest childbirth provides a possible explanation for her sensitization. The transfusion involving Rh(D) positive blood might have triggered the production of Anti-D antibodies in her immune system. These antibodies can pose a risk to the current pregnancy if the foetus is Rh(D) positive, leading to HDFN (Booth and Allard, 2017).
Are you looking to buy HCS329 Case Study Analysis and Solutions? You are at the right place. Mail us at onlineassignmentservices1@gmail.com.
Question 3
The third solution is based on a thorough examination and contrast of the pathophysiology of the detected condition caused by the antibodies found in patients 1 and 2. In addition, our experts have also remarked on the potential preventative measures or ways to monitor the ailment’s progression in providing this HCS329 Clinical Case Study Assignment Help.
The identified condition in both Patient 1 and Patient 2 is Rh(D) alloimmunization, which occurs when an Rh(D) negative individual is sensitized to the Rh(D) antigen through exposure to Rh(D) positive red blood cells. However, there are some differences in the pathogenesis of this condition between the two patients. Patient 1 experienced Rh(D) alloimmunization during a previous pregnancy that was Rh(D) positive. Her circulation was invaded by lethal Rh(D) positive red blood cells, which resulted in an immunological reaction and the creation of Anti-D antibodies. If the foetus is Rh(D) positive, these antibodies may cross the placenta during successive pregnancies, which might result in HDFN (haemolytic disease of the foetus and newborn) (McBain, Crowther and Middleton, 2015). McBain, Crowther and Middleton (2015) also highlight that the antibodies target and destroy the foetal Rh(D) positive red blood cells, causing foetal anaemia, jaundice, and other complications. In contrast, Patient 2 developed Rh(D) alloimmunization through a different mechanism. It is stated that due to post-partum haemorrhage, she needed a blood transfusion while giving birth to her most recent child. This blood transfusion involved Rh(D) positive blood, which sensitized her immune system to the Rh(D) antigen (Yazer et al., 2021). As a result, Patient 2’s immune system produced Anti-D antibodies that can cross the placenta and cause HDFN in subsequent Rh(D) positive pregnancies.
Pursuing a BSc in Biomedical Sciences and need Assignment Help at affordable prices? Don’t worry! WhatsApp us at +447700174710 today.
Question 4
Here, our experts have assessed the existing methods for measuring the corresponding antibodies while also elaborating on the potential clinical ramifications of the range of antibody levels in light of the laboratory results. Our experts have supported the judgments here regarding the probable severity of the condition using relevant and credible literature sources to provide the best-quality University of Sunderland Assignment Help.
Patient 1 and Patient 2 underwent antibody quantification tests to measure the levels of their respective antibodies. By evaluating the potential clinical consequences of the series of antibody levels in the plasma of both patients regarding the health of their foetuses by comparing the findings of the antibody quantification. In Patient 1, the antibody quantification results (Table 4) demonstrate a gradual increase in the levels of Anti-D antibodies with advancing gestational age. This trend indicates ongoing sensitization and production of antibodies. At 32 weeks, the quantification result shows a level of 14.5 IU/ml While there are no published guidelines specifically mentioned in the information provided, it is known that the clinical significance of Anti-D antibody levels depends on various factors, including the presence of other risk factors, such as the father’s Rh status and any signs of foetal compromise (Daniels, 2013). To assess the severity of disease and potential risk to the foetus, further tests and monitoring would be necessary. Doppler ultrasound of the middle cerebral artery can be performed to measure peak systolic velocity (PSV), which correlates with the severity of foetal anaemia (Kaczynski et al., 2018).
We offer the best Hematology and Transfusion Science Assignment help in the UK. Don’t believe us? Get in touch with us to know more about how we provide personalized assistance to our students. Call us at +61 871501720.
